St Ephraem the Syrian speaks of the Refuges too

http://www.bibliotecapleyades.net/profecias/esp_profecia01c1a.htm#3.%20St.%20Ephrem%20~

"But before these things be, the Lord sendeth Elias the Thesbite and Enoch the compassionate, that they may proclaim reverence to the race of men, and openly announce unto all the knowledge of God, that they believe not nor obey the false one through fear, crying out and saying, "A deceiver, O men, is he; let no one believe in him." But few are those who shall then obey and believe in the words of these two prophets.

    "Many therefore of the saints as many are then found, as soon as they shall hear of the coming of the man of corruption, shall most speedily flee to the deserts and lie hid in the deserts and mountains and caves through fear, and strew earth and ashes on their heads, destitute and weeping both day and night with great humility. And this shall to them be granted by God the Holy One: And grace shall lead them unto the appointed places.